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Updated: Aug 11, 2026
07:57
Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
Published on: August 25, 2022
[Intracranial hemorrhage in term newborn]
Tomasz Tomasik1, Zofia Mitkowska, Przemko Kwinta
1Klinika Chorób Dzieci Katedry, Pediatrii Polsko-Amerykański Instytut Pediatrii, Collegium Medicum, Uniwersytetu Jagiellońskiego, Kraków.
Przeglad Lekarski
|March 4, 2006
Summary
Delivery complications, skull fractures, and nuchal cords are key risk factors for intracranial hemorrhage (ICH) in newborns. Early diagnosis using advanced imaging is crucial for managing ICH in full-term infants.
Area of Science:
- Neonatal Medicine
- Pediatric Neurology
- Medical Imaging
Background:
- Advances in perinatal care have altered the presentation of intracranial hemorrhage (ICH) in term newborns.
- Modern imaging techniques enable the detection of ICH even in asymptomatic infants.
Purpose of the Study:
- To analyze the prevalence and identify risk factors for ICH in term newborns admitted to a Neonatal Intensive Care Unit.
- To evaluate the clinical presentation and outcomes of ICH in this population.
Main Methods:
- Retrospective analysis of 397 term newborns in a tertiary Neonatal Intensive Care Unit.
- Inclusion of detailed neurological evaluations and diagnostic imaging (head ultrasound, CT, or MRI) and/or cerebrospinal fluid analysis.
Main Results:
- Intracranial hemorrhage (ICH) was diagnosed in 40 newborns (10.1%).
- Subarachnoid hemorrhage was the most common type (n=24), with multifocal bleeding occurring in 28/40 infants.
- Significant independent risk factors identified included delivery complications (OR: 10.4), skull fractures (OR: 44.4), nuchal cord (OR: 6.4), and hemorrhagic diathesis (OR: 4.5).
- Mortality due to ICH was observed in 11 newborns.
Conclusions:
- Mechanical trauma (labor complications, skull fractures), nuchal cord, and hemorrhagic diathesis are significant risk factors for ICH in term neonates requiring intensive care.
- Comprehensive neurological assessment and advanced imaging (CT/MRI) are recommended due to limitations of ultrasound in visualizing certain bleeding locations.
- Multifocal bleeding is the predominant form of ICH in this cohort.
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