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Updated: Aug 11, 2026
Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
[Study on vascular endothelial injuries and inflammation related cytokines in patients with multiple organ
1Department of Emergency, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shanxi, China. wangjinghehe@sina.com
Objective:
To investigate the relationship between the circulating endothelial cell (CEC), coagulation, fibrinolysis indexes and inflammation related cytokines in patients with multiple organ dysfunction syndrome (MODS).
Methods:
Thirty-five patients with MODS (MODS group) and 20 healthy individuals (control group) were enrolled for study. CECs were harvested by isopycnic centrifugation method. Plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FG), D-dimer, and serum tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) were determined simultaneously. The relationship between dynamic changes in CEC, TNF-alpha, IL-6 and that in PT, APTT, FG, D-dimer was analyzed.
Results:
Compared to the control group, CEC numbers, serum TNF-alpha, IL-6 levels and plasma D-dimer level significantly increased, PT and APTT were prolonged, and FG significantly decreased in MODS group (all P<0.05). The quantity of CEC and serum levels of TNF-alpha and IL-6 elevated with the lapse of time. Correlation analysis revealed a significant positive correlation between CEC and serum levels of TNF-alpha and IL-6 (r(1)=0.536, P(1)=0.000; r(2)=0.412, P(2)=0.002), and the same correlation between serum TNF-alpha, IL-6 levels and PT, APTT.
Conclusion:
Elevation of serum inflammation related cytokines and vascular endothelial cell damage occur in MODS patients. Serum inflammation related cytokines play an important role in endothelial damage, and an increase in CEC number may be attributed to vessel injury.
Insights
Circulating endothelial cell (CEC) damage and inflammation are elevated in multiple organ dysfunction syndrome (MODS). Inflammatory cytokines contribute to endothelial damage and increased CECs in MODS patients.
Area of Science:
- Biomedical science
- Pathophysiology
- Clinical research
Context:
- Multiple organ dysfunction syndrome (MODS) is a critical condition with high mortality.
- Endothelial dysfunction and systemic inflammation are key features of MODS.
- Understanding the interplay between endothelial cells, coagulation, and inflammation is crucial for managing MODS.
Purpose:
- To investigate the relationship between circulating endothelial cells (CECs), coagulation/fibrinolysis markers, and inflammatory cytokines in MODS patients.
- To determine the role of inflammation in endothelial damage within the context of MODS.
- To explore potential biomarkers for MODS progression and severity.
Summary:
- Patients with MODS exhibited significantly higher levels of CECs, pro-inflammatory cytokines (TNF-alpha, IL-6), and D-dimer compared to healthy controls.
- Coagulation parameters (PT, APTT) were prolonged, and fibrinogen levels were decreased in MODS patients.
- A significant positive correlation was observed between CEC counts, inflammatory cytokine levels, and coagulation markers, indicating a strong link between endothelial injury and systemic inflammation in MODS.
Impact:
- Findings suggest that elevated inflammatory cytokines contribute to endothelial damage in MODS.
- Increased CEC numbers may serve as an indicator of vascular injury in MODS.
- This research provides insights into the pathophysiology of MODS, potentially guiding future therapeutic strategies targeting endothelial protection and inflammation modulation.
