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Related Experiment Videos

Experience with CHART.

M I Saunders1, S Dische, E J Grosch

  • 1Marie Curie Research Wing for Oncology, Mount Vernon Hospital, Northwood, Middlesex, UK.

International Journal of Radiation Oncology, Biology, Physics
|August 1, 1991
PubMed
Summary
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Continuous, hyperfractionated, accelerated radiotherapy (CHART) shows improved tumor control for head and neck and lung cancers. This advanced radiation therapy also reduces late side effects compared to conventional methods.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Clinical Trials

Background:

  • Continuous, hyperfractionated, accelerated radiotherapy (CHART) is an advanced radiation therapy technique.
  • CHART has been implemented at Mount Vernon Cancer Treatment Center since 1985.
  • The majority of patients treated with CHART have head and neck tumors or locally advanced non-oat cell lung carcinoma.

Purpose of the Study:

  • To evaluate the efficacy and toxicity of CHART in patients with head and neck and lung cancers.
  • To compare CHART outcomes with conventional radiotherapy.
  • To assess the impact of CHART on tumor regression, survival rates, and late treatment-related morbidity.

Main Methods:

  • Retrospective analysis of 263 patients treated with CHART.

Related Experiment Videos

  • Comparison of outcomes (tumor regression, survival, late morbidity) with historical control groups treated with conventional radiotherapy.
  • Detailed assessment of early and late reactions in skin, mucosae, connective tissues, and salivary glands.

    • Main Results:

    • Complete tumor regression rates were 90% for head and neck cancers (vs. 62% historically) and 40% for lung cancers (vs. 12% historically).
    • 1-year and 2-year survival rates were significantly improved with CHART for lung cancer patients (60% vs. 40% and 29% vs. 12%, respectively).
    • Early mucosal reactions were pronounced but healed; skin reactions were less severe than conventional radiotherapy, and late changes appeared reduced, with the exception of radiation myelitis in four patients.

    Conclusions:

    • CHART demonstrates superior tumor control and improved survival for specific cancer types compared to conventional radiotherapy.
    • CHART shows a potential for reduced late morbidity, although radiation myelitis requires careful monitoring.
    • The promising results support ongoing multi-center randomized controlled trials comparing CHART with conventional fractionated radiotherapy.