Modeling the statistics of elementary calcium release events

Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the release of Ca(2+) from endoplasmic reticulum through small clusters of inositol 1,4,5-trisphosphate receptors, are the building blocks for intracellular Ca(2+) signaling. The small number of release channels involved during a Ca(2+) puff renders the puffs stochastic, with distributed amplitudes, durations, and frequency, well characterized experimentally. We present a stochastic model that accurately describes simultaneously the statistical properties of the duration, amplitudes, frequencies, and spatial spread with a single set of parameters.