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Dysbindin genotype and negative symptoms in schizophrenia
Pamela DeRosse1, Birgit Funke, Katherine E Burdick
1Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, USA. pderosse@lij.edu
The American Journal of Psychiatry
|March 4, 2006
Summary
Genetic variations in the dysbindin gene (DTNBP1) are linked to schizophrenia. This study found a significant association between a DTNBP1 risk haplotype and negative symptoms in schizophrenia patients.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Growing evidence links dysbindin gene (DTNBP1) variants to schizophrenia.
- A specific DTNBP1 risk haplotype is associated with schizophrenia and neurocognitive deficits.
- Neurocognitive dysfunction in schizophrenia often co-occurs with negative symptoms.
Purpose of the Study:
- To investigate the association between the DTNBP1 risk haplotype and negative symptoms in schizophrenia.
- To test the hypothesis that the DTNBP1 risk haplotype is linked to negative symptom presentation.
Main Methods:
- Examined the association between a DTNBP1 risk haplotype and a history of negative symptoms.
- Study included 181 Caucasian patients diagnosed with schizophrenia.
Main Results:
- A statistically significant association was identified between the presence of the DTNBP1 risk haplotype and negative symptoms.
- The findings support a link between this genetic variation and symptomology.
Conclusions:
- DTNBP1 genetic variations may influence the manifestation of negative symptoms in schizophrenia.
- Further research can explore the specific mechanisms linking DTNBP1 to negative symptoms.
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