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Updated: Aug 11, 2026

Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
Published on: March 16, 2016
The role of neural activity in cortical axon branching
Naofumi Uesaka1, Edward S Ruthazer, Nobuhiko Yamamoto
1Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
Abstract:
Axonal branching is an important process for establishing the final pattern of connections between a neuron and its target cells. Cortical connections between upper-layer cells in the neocortex have provided insights into the cellular mechanisms by which electrical activity regulates neural connectivity, including branch formation. Recent evidence further indicates that spontaneous firing and synaptic transmission contribute to axonal branching of cortical neurons through postsynaptic activation.
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