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Related Experiment Videos

[Plasma thrombomodulin levels in elderly subjects].

A Deguchi1, K Kawamura, H Wada

  • 1Oyamada Memorial Spa Hospital.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|March 1, 1991
PubMed
Summary

Thrombomodulin (TM) levels are elevated in elderly individuals and patients with hypercoagulable states, indicating endothelial injury. Higher TM levels in diabetic patients, especially those with retinopathy, further support its role as an endothelial injury marker.

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[Coagulation/fibrinolysis disorders in the elderly].

Rinsho byori. The Japanese journal of clinical pathology·2000

Area of Science:

  • Biochemistry
  • Hematology
  • Vascular Biology

Context:

  • Investigating plasma levels of thrombomodulin (TM), fibrinogen, antithrombin III (ATIII), and thrombin ATIII complex (TAT).
  • Comparing healthy young subjects (Group A), healthy elderly subjects (Group B), and patients (Group C).
  • Assessing markers of coagulation and endothelial injury in different age and health groups.

Purpose:

  • To evaluate plasma TM levels as a potential marker for endothelial injury.
  • To explore the relationship between TM levels and hypercoagulable states.
  • To investigate TM levels in relation to diabetes mellitus and diabetic retinopathy.

Summary:

  • Plasma TM levels were higher in elderly subjects (Group B) than young subjects (Group A).
  • Group C exhibited elevated TM, fibrinogen, and TAT, suggesting a hypercoagulable state.

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  • In diabetic patients (Group C with DM), TM levels were higher, particularly in those with diabetic retinopathy, indicating endothelial damage.

    • Impact:

    • High TM levels correlate with hypercoagulable states and endothelial injury.
    • TM emerges as a potential biomarker for detecting endothelial dysfunction.
    • Findings contribute to understanding coagulation abnormalities in aging, diabetes, and related complications.