Recording rod ON and OFF responses in ERG and multifocal ERG

The 5 Hz rectangle stimulus was generally used to record cone ON and OFF response. In this study, the feasibility and recording conditions of recording rod ON and OFF responses in electroretinograms (ERG) and multifocal electroretinograms (mf-ERG) were described, and the character and influence factors of these responses were observed. The result demonstrated that the rod ON and OFF responses of ERG can be recorded with sawtooth rapid-on and rapid-off stimulus. There is a small positive wave in downhill of negative wave in rod OFF response. Rod ON response of mf-ERG can be recorded with simulated rapid-on stimulus. We speculated that the simulated rapid-ON, sawtooth rapid-on and rapid-off stimulus can be an useful tool to investigate retinal disease and have certain clinical values.