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Related Experiment Videos

Polydimethylsiloxane particles for permanent injection laryngoplasty.

Christian Sittel1, Matthias Echternach, Philipp A Federspil

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany.

The Annals of Otology, Rhinology, and Laryngology
|March 7, 2006
PubMed
Summary

Polydimethylsiloxane (PDMS) particle injections offer a safe, minimally invasive method for permanent vocal fold augmentation. This treatment significantly improved voice quality in patients with unilateral vocal fold paralysis.

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Area of Science:

  • Otolaryngology
  • Vocal fold augmentation
  • Biomaterials

Background:

  • Unilateral vocal fold paralysis can lead to significant voice impairment.
  • Polydimethylsiloxane (PDMS) particles are a nonresorbable biomaterial for permanent vocal fold augmentation.
  • Assessing the safety and efficacy of PDMS particle injection for vocal fold paralysis is crucial.

Purpose of the Study:

  • To investigate the morbidity and voice quality outcomes in patients treated for unilateral vocal fold paralysis using PDMS particle injections.
  • To evaluate the safety profile of PDMS particle injections for vocal fold augmentation.

Main Methods:

  • A prospective study included fourteen patients with neurogenic unilateral vocal fold paralysis.
  • Videostroboscopic assessment and Friedrich's dysphonia index (DI) were used to evaluate voice quality before and after the procedure.

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  • PDMS particles were injected into the paraglottic space via microlaryngoscopy under general anesthesia.

    • Main Results:

    • No complications were reported in relation to PDMS particle injections.
    • The mean pre-operative Dysphonia Index (DI) was 2.8, indicating severe voice impairment.
    • Significant voice quality improvement was observed post-injection, with a mean DI of 1.4.

    Conclusions:

    • PDMS particles represent a safe and minimally invasive option for permanent vocal fold augmentation.
    • The voice improvement achieved with PDMS particles is comparable to other established techniques like thyroplasty.
    • PDMS particles are approved for laryngeal use within the European Community.