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Published on: April 8, 2013

[Allicor efficacy in lowering the risk of ischemic heart disease in primary prophylaxis]

I A Sobenin, V V Prianishnikov, L M Kunnova

    Terapevticheskii Arkhiv
    |March 7, 2006
    PubMed

    Insights

    Long-acting garlic drug Allicor effectively reduces the risk of ischemic heart disease (IHD) and cardiovascular events in patients with hyperlipidemia. This study demonstrates Allicor

    Area of Science:

    • Cardiovascular Medicine
    • Pharmacology
    • Nutraceuticals

    Context:

    • Cardiovascular diseases (CVD) represent a significant global health burden.
    • Hyperlipidemia is a major risk factor for CVD, including ischemic heart disease (IHD).
    • Primary prophylaxis strategies are crucial for managing cardiovascular risk in asymptomatic individuals.

    Purpose:

    • To evaluate the efficacy of Allicor, a long-acting garlic preparation, in reducing the multifactorial risk of cardiovascular diseases.
    • To assess the impact of Allicor on the risk of developing IHD and its complications.
    • To investigate the effects of Allicor on lipid profiles in patients with hyperlipidemia.

    Summary:

    • A 12-month, double-blind, placebo-controlled study involving 167 patients with hyperlipidemia and no prior IHD.
    • Allicor intake significantly reduced the 10-year absolute risk of IHD by 10.7% in men (p < 0.05).
    • Allicor decreased the 10-year risk of acute myocardial infarction and sudden death by 22.7% in men (p < 0.05) and prevented age-related cardiovascular risk in women (p < 0.05).
    • Significant reductions in total cholesterol and LDL-C were observed in both men and women.

    Impact:

    • Allicor demonstrates significant potential as a therapeutic agent for primary cardiovascular disease prevention.
    • The findings support the use of Allicor in managing hyperlipidemia and reducing overall cardiovascular risk.
    • This research contributes to understanding the role of garlic-based interventions in cardiovascular health.
    Abstract

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