Related Experiment Video
Updated: Aug 11, 2026

08:21
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
Published on: June 15, 2020
[Right ventricular function and pulmonary circulation hemodynamics in patients with vibration disease]
Terapevticheskii Arkhiv
|March 7, 2006
Summary
Vibration disease (VD) impairs right heart function, leading to heart failure. Early diagnosis and prevention are crucial for individuals exposed to vibration to mitigate cardiac risks.
Area of Science:
- Cardiology
- Occupational Medicine
- Cardiovascular Physiology
Background:
- Vibration exposure is linked to occupational health risks.
- Vibration disease (VD) may affect cardiovascular function.
- Understanding the impact of VD on the heart is essential for early intervention.
Purpose of the Study:
- To investigate right ventricle contractile and diastolic function in patients with VD.
- To assess the mechanical activity of the right heart in VD.
- To examine pulmonary circulation hemodynamics in individuals with VD.
Main Methods:
- Study included 15 subjects without VD, 44 patients with VD (1st-2nd degree), and 20 controls.
- Evaluated right ventricular function, right heart mechanics, and pulmonary hemodynamics.
- Compared findings between vibration-exposed individuals and controls.
Main Results:
- Patients with VD exhibited right ventricular dysfunction, including impaired diastolic function and hypodynamic syndrome.
- Reduced ejection fraction, stroke output, and cardiac index were observed in VD patients.
- Right ventricular dysfunction in VD occurs concurrently with left ventricular dysfunction, influenced by pulmonary hypertension and interventricular interaction.
Conclusions:
- Specific alterations in pulmonary circulation and right ventricular function in VD contribute to heart failure development.
- Early diagnostic and prophylactic measures are recommended for individuals exposed to vibration.
- Timely intervention can help prevent or manage heart failure in vibration-exposed workers.
Related Concept Videos
Imbalances in Cardiac Output
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Pulmonary Hypertension: Classification and Pathogenesis
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Factors Affecting Pulmonary Ventilation
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Assessment of Ventilation II: Respiratory Depth and Rhythm
Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:

