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Updated: Aug 11, 2026

Cost-Efficient Transcriptomic-Based Drug Screening
Published on: February 23, 2024
Gene expression profiling in the discovery, optimization and development of novel drugs: one universal screening
1Avalon Pharmaceuticals, Inc., 20358 Seneca Meadows Parkway, Germantown, MD 20876, USA. dbol@avalonrx.com
Abstract:
With recent advances in robotics and high-content screening and analysis methods, transcriptional profiling can now be utilized as a comprehensive forward chemical genomics platform for drug discovery, lead selection and lead optimization. It can be used to define the state of a cell on the basis of gene networks, and to search for drugs that can shift cellular states in a manner predicted at the genome level to be therapeutically beneficial. The treatment of cells with compounds produces transcriptional 'fingerprints' that reveal mechanism-of-action, and enable discrimination between individual compounds based on drug behaviors important to all phases of drug discovery and development.
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