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Updated: Aug 11, 2026
10:24
A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Antimitotic agents of natural origin
Advait Nagle1, Wooyoung Hur, Nathanael S Gray
1Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Drive, San Diego, CA 92121, USA.
Current Drug Targets
|March 7, 2006
Summary
Antimitotic agents, crucial for cancer treatment, are expanding beyond traditional tubulin targets. This review explores new compounds and protein targets that block cell division (mitosis).
Area of Science:
- Pharmacology
- Cancer Biology
- Cell Biology
Background:
- Antimitotic agents are highly successful cancer therapeutics.
- Traditionally, these agents targeted tubulin.
- Recent discoveries necessitate a broader definition of antimitotic agents.
Purpose of the Study:
- To provide a comprehensive overview of antimitotic compounds.
- To identify novel protein targets involved in mitotic arrest.
- To focus on agents directly impacting the mitotic machinery.
Main Methods:
- Literature review of recent antimitotic compounds.
- Analysis of identified protein targets.
- Categorization of agents based on their mechanism of action.
Main Results:
- A diverse range of new antimitotic agents and their targets have been identified.
- These agents exhibit varied mechanisms for inducing mitotic block.
- The focus is on direct disruption of the mitotic process.
Conclusions:
- The definition of antimitotic agents requires expansion.
- Novel targets beyond tubulin are crucial for cancer therapy.
- Directly targeting the mitotic machinery offers promising therapeutic strategies.
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