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Updated: Aug 11, 2026
Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients?
Cinzia Scambi1, Patrizia Guarini, Lucia De Franceschi
1Department of Clinical and Experimental Medicine, University of Verona, Chair of Internal Medicine B, 37134 Verona, Italy. cinzia.scambi@medicina.univr.it <cinzia.scambi@medicina.univr.it>
Abstract:
Recent studies have reported an imbalance between n6 and n3 fatty acids (AA and DHA) in subjects with CF. Alterations in fatty acid amounts are present in CFTR-expressing tissues, plasma and in circulating blood cells. It has been reported that the correction of polyunsaturated fatty acid deficiency reversed the organ pathologies observed in CF knockout mice. We describe a CF child with an unusual clinical course presenting high molar percentage of DHA in plasma and red cells membrane during supplementation with 5-methyltetrahydrofolate and vitamin B12.
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