Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current and future centrally acting antitussives.

Donald C Bolser1

  • 1Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. bolserd@mail.vetmed.ufl.edu

Respiratory Physiology & Neurobiology
|March 7, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling insights into potential mechanisms of opioid-induced respiratory depression within medullary and pontine networks.

Journal of neurophysiology·2026
Same author

Changes in cough motor output during repetitive mechanical stimulation of the tracheobronchial tree in cats.

Respiratory physiology & neurobiology·2025
Same author

Effects of baclofen on swallow motor pattern.

Frontiers in neurology·2025
Same author

Modeling Insights into Potential Mechanisms of Opioid-Induced Respiratory Depression within Medullary and Pontine Networks.

bioRxiv : the preprint server for biology·2025
Same author

Peripheral antitussives affect temporal features of tracheobronchial coughing in cats.

Journal of applied physiology (Bethesda, Md. : 1985)·2024
Same author

Amygdalar involvement in respiratory dysfunction.

Frontiers in physiology·2024

Current cough suppressants like codeine may be less effective for upper airway coughs. Future drug development requires understanding how cough signals are processed in the central nervous system.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Respiratory Medicine

Background:

  • Centrally acting antitussive drugs are classified based on animal models.
  • Prominent examples include codeine and dextromethorphan, thought to inhibit the cough gating mechanism.
  • Their exact neural targets remain unknown.

Purpose of the Study:

  • To review issues with current centrally acting antitussive drugs.
  • To discuss implications for developing future cough suppressants.
  • To explore the differential efficacy of antitussives in humans.

Main Methods:

  • Review of existing literature on antitussive drug mechanisms and efficacy.
  • Analysis of evidence from animal models and human studies.
  • Hypothesis generation regarding differential central processing of cough signals.

Related Experiment Videos

Main Results:

  • Efficacy of codeine and dextromethorphan in humans is questioned.
  • These drugs show reduced effectiveness for coughs induced by upper airway disorders compared to lower airway conditions.
  • Animal models suggest differential sensitivity of laryngeal and tracheobronchial cough to codeine.

Conclusions:

  • Human cough suppression may involve antitussive-sensitive and insensitive central pathways.
  • Sensory input from different airway regions and central pathway plasticity are important factors.
  • Further research is needed to develop more effective cough suppressants.