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Updated: Aug 11, 2026

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage
Published on: January 17, 2013
Hypersensitivity to hydroxyl radicals in rat basilar artery after subarachnoid hemorrhage
Tsuyoshi Nishihashi1, Cristina C Trandafir, Aimin Wang
1Pharmacology Division, RI Center, Kyoto University, Kyoto 606-8501, Japan.
Abstract:
Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3-6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.
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