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Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Modulation of tumor necrosis factor by microbial pathogens
Masmudur M Rahman1, Grant McFadden
1BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada.
Microbes like viruses and bacteria have evolved strategies to evade host defenses by targeting tumor necrosis factor (TNF), a key inflammatory cytokine. Understanding these microbial tactics offers insights into treating inflammatory and autoimmune diseases.
Area of Science:
- Immunology
- Microbial Pathogenesis
- Molecular Biology
Background:
- Host immune responses involve innate and adaptive immunity.
- Tumor necrosis factor (TNF) is a critical pro-inflammatory cytokine mediating diverse cellular functions.
- Pathogens have developed mechanisms to counteract TNF-mediated host defenses.
Purpose of the Study:
- To review microbial strategies for evading or manipulating TNF-mediated immune responses.
- To explore how understanding TNF modulation by pathogens can inform disease treatment.
Main Methods:
- Literature review of microbial evasion tactics.
- Analysis of viral and bacterial mechanisms targeting TNF signaling pathways.
- Synthesis of information on host-pathogen interactions concerning TNF.
Main Results:
- Viruses use modulatory proteins to block TNF at ligand, receptor, or signaling molecule levels.
- Bacteria primarily modify components of the TNF signaling pathway.
- Pathogen strategies highlight the importance and complexity of TNF in host defense.
Conclusions:
- Investigating microbial TNF regulation advances understanding of pathogenesis.
- Insights into TNF modulation by pathogens may lead to novel therapeutic strategies for inflammatory and autoimmune diseases.
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