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Updated: Aug 11, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Molecular regulation of androgen action in prostate cancer

Scott M Dehm1, Donald J Tindall

  • 1Department of Urology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

Journal of Cellular Biochemistry
|March 7, 2006
PubMed

Insights

Androgens regulate prostate function and cancer growth. This review explores androgen-regulated genes and their role in prostate cancer development and resistance to androgen ablation therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Androgens are key regulators of prostate gland function and development.
  • Androgen ablation is a primary treatment for advanced prostate cancer.
  • The androgen receptor (AR) mediates androgen action through gene regulation.

Purpose of the Study:

  • To review the androgen-regulated gene expression program in prostate cancer.
  • To examine the role of newly identified androgen-regulated genes in prostate cancer progression.
  • To summarize research on gene deregulation in castration-resistant prostate cancer.

Main Methods:

  • Review of recent gene expression profiling studies.
  • Analysis of traditional single-gene characterization studies.
  • Synthesis of findings on androgen-regulated genes in normal and malignant prostate tissues.

Main Results:

  • Numerous androgen-regulated genes have been identified.
  • These genes are crucial mediators of androgen action in prostate tissues.
  • Understanding these genes is vital for comprehending prostate cancer development.

Conclusions:

  • Androgen-regulated genes significantly influence prostate cancer growth and survival.
  • Further research into these genes may reveal new therapeutic targets.
  • Investigating gene deregulation is essential for overcoming treatment resistance.

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