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Aspirin therapy as primary prevention in hypertensive patients at Srinagarind hospital

Kittisak Sawanyawisuth1, Panita Limpawattana, Sauwanan Bumrerraj

  • 1Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. kittisak@kku.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|March 8, 2006
PubMed

Insights

Aspirin use for cardiovascular event prevention in hypertensive patients over 50 is low, with many receiving suboptimal doses. However, aspirin therapy showed no serious side effects in this study.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Clinical Pharmacy

Background:

  • Aspirin is recommended for cardiovascular event prevention, particularly in diabetic and hypertensive patients.
  • Hypertension is a significant risk factor for atherosclerosis.
  • Guidelines exist for aspirin therapy in at-risk populations.

Purpose of the Study:

  • To investigate the rate of aspirin use for primary prevention in hypertensive patients.
  • To assess aspirin prescribing patterns and dosage in this cohort.

Main Methods:

  • Retrospective study of hypertensive patients aged over 50 at Srinagarind Hospital.
  • Evaluation of adherence to 2003 European Society of Hypertension (ESH) guidelines for aspirin therapy.
  • Analysis of prescribed aspirin dosage and one-year follow-up for side effects.

Main Results:

  • Only 18.9% of eligible hypertensive patients (31 of 164) were prescribed aspirin for primary prevention.
  • The most common aspirin dose was 60 mg/day, lower than recommended.
  • No serious adverse events, such as upper gastrointestinal bleeding, were reported during the one-year follow-up.

Conclusions:

  • Aspirin prescribing for primary cardiovascular prevention in hypertensive patients over 50 is suboptimal.
  • Lower-than-recommended aspirin doses are frequently used.
  • Aspirin appears safe for primary prevention in this population, warranting further investigation into optimal prescribing.

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