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Updated: Aug 11, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
[Expression and implication of cyclooxygenase-2 mRNA in prostate cancer]
Ming-Shan Yang1, Shu-Jie Xia, Hai-Tao Liu
1Department of Urology, the First Hospital of Shanghai Jiaotong University, Shanghai 200080, China. yangmingshandachuan@126.com
Objective:
To investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa).
Methods:
The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined. Seven normal prostate tissues were served as control.
Results:
The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative. There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa. There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.
Conclusion:
COX-2 mRNA play an important role in occurrence and progression of the PCa. COX-2 is a tumor marker which may be the possible prognostic factor of PCa.
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