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Updated: Aug 11, 2026
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Systemic fungal infections in neonates
1Department of Pediatrics, BJ Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai, India. c_sudha@hotmail.com
Journal of Postgraduate Medicine
|March 8, 2006
Summary
Systemic fungal infections, primarily Candida, are a major threat to newborns. A new Indian liposomal Amphotericin B (L-Amp-LRC-1) shows promise as a safer, effective, and affordable treatment for neonatal candidiasis.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Pharmacology
Background:
- Neonatal infections, both bacterial and fungal, are significant causes of morbidity and mortality in newborns.
- Candida species, particularly Candida albicans, are the most common cause of fungal infections in Neonatal Intensive Care Units (NICUs).
- Fungal colonization is common in NICU infants, increasing the risk of disseminated candidiasis affecting multiple organs.
Purpose of the Study:
- To evaluate the safety and efficacy of a novel Indian liposomal Amphotericin B formulation (L-Amp-LRC-1) for treating systemic fungal infections in neonates.
- To compare the therapeutic profile of L-Amp-LRC-1 with existing Amphotericin B formulations.
Main Methods:
- A clinical trial was conducted to assess the safety and efficacy of L-Amp-LRC-1 in neonatal fungal infections.
- Laboratory confirmation of fungemia was based on organism recovery from blood or sterile bodily fluids.
Main Results:
- The Indian liposomal Amphotericin B (L-Amp-LRC-1) demonstrated a good response with reduced toxicity in neonatal fungal infections.
- The trial confirmed L-Amp-LRC-1 to be safe and efficacious in this vulnerable population.
- L-Amp-LRC-1 was found to be effective at a lower dose and is less expensive than other liposomal preparations.
Conclusions:
- L-Amp-LRC-1 represents a promising, cost-effective therapeutic option for neonatal candidiasis.
- This new formulation offers a potentially safer alternative to conventional Amphotericin B, with reduced risks of nephrotoxicity and hypokalemia.
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