Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA-accelerated atom transfer radical polymerization on a gold surface.

Xinhui Lou1, Lin He

  • 1Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 8, 2006
PubMed
Summary

DNA molecules significantly accelerate polymer growth rates in surface-initiated atom transfer radical polymerization (ATRP). This effect, observed with poly(2-hydroxyethyl methacrylate) and poly(oligoethylene glycol methacrylate), is attributed to DNA

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association study of APC polymorphisms with colorectal cancer in Han Chinese.

Clinical biochemistry·2012
Same author

Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia.

Molecular bioSystems·2012
Same author

A role for c-Abl in cell senescence and spontaneous immortalization.

Age (Dordrecht, Netherlands)·2012
Same author

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

Nature genetics·2012
Same author

c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.

Nature cell biology·2012
Same author

Dynamic network of transcription and pathway crosstalk to reveal molecular mechanism of MGd-treated human lung cancer cells.

PloS one·2012

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Surface Science

Background:

  • Surface-initiated atom transfer radical polymerization (ATRP) is a controlled polymerization technique.
  • DNA molecules can be functionalized for surface immobilization and biomaterial applications.

Purpose of the Study:

  • To investigate the effect of DNA molecules on polymer growth rates during surface-initiated ATRP.
  • To understand the mechanism behind DNA-mediated acceleration of polymerization.

Main Methods:

  • Utilized thiolated single-stranded DNA (ssDNA) with ATRP initiators for surface grafting.
  • Employed 2-hydroxyethyl methacrylate (HEMA) and oligo(ethylene glycol) methacrylate (OEGMA) as ATRP monomers.
  • Monitored polymer film thickness over time to determine growth rates.

Related Experiment Videos

Main Results:

  • DNA presence, even at <1% surface coverage, significantly accelerated initial polymer growth rates for PHEMA and POEGMA.
  • The acceleration is hypothesized to result from DNA's charged backbone and copper complexation with DNA bases.
  • A reduced, constant growth rate was observed after initial acceleration, indicating decreased DNA influence.

Conclusions:

  • DNA molecules can act as effective accelerators for surface-initiated ATRP.
  • Polymerization kinetics are influenced by surface-bound DNA, with optimal catalyst conditions identified.
  • This finding opens possibilities for DNA-templated polymer synthesis and functional surface modification.