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Updated: Aug 11, 2026
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
The effect of betamethasone administration on uterine motility in pregnancy. A prospective study using four-channel
Falk Fallenstein1, Harald Busch, Claudia Behrens
1Department of Obstetrics and Gynecology, Klinikum Fulda, Fulda, Germany. fallenstein@hawkbit.de
We monitored 30 patients before and after betamethasone prophylaxis using four-channel tocography to evaluate if betamethasone therapy in the case of imminent preterm delivery increases uterine activity. Frequency of contractions slightly increased but global uterine activity decreased. We conclude that the changed contraction pattern did not impair the benefits of RDS prophylaxis.
We monitored 30 patients before and after betamethasone prophylaxis using four-channel tocography to evaluate if betamethasone therapy in the case of imminent preterm delivery increases uterine activity. Frequency of contractions slightly increased but global uterine activity decreased. We conclude that the changed contraction pattern did not impair the benefits of RDS prophylaxis.
