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Related Experiment Videos

Pentose phosphates in nucleoside interconversion and catabolism.

Maria G Tozzi1, Marcella Camici, Laura Mascia

  • 1Dipartimento di Biologia, Laboratorio di Biochimica, Pisa, Italy.

The FEBS Journal
|March 8, 2006
PubMed
Summary
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Pentose phosphates, vital for nucleotide synthesis, are produced via the pentose phosphate pathway or nucleoside phosphorylases. This review details how these pathways recycle or catabolize pentose phosphates for energy and biosynthesis.

Area of Science:

  • Biochemistry
  • Metabolic Pathways
  • Nucleotide Metabolism

Background:

  • Ribose phosphates are central to nucleotide synthesis, originating from the pentose phosphate pathway or nucleoside phosphorylases.
  • Interconversion of ribose-1-phosphate and ribose-5-phosphate is facilitated by phosphopentomutase.
  • Ribose-5-phosphate is a key precursor for both de novo and salvage nucleotide synthesis.

Purpose of the Study:

  • To review molecular mechanisms governing pentose phosphate metabolism from nucleoside phosphorolysis.
  • To elucidate pathways for recycling or catabolizing pentose phosphates as carbon and energy sources.
  • To detail the anabolic and catabolic roles of specific nucleoside phosphorylases.

Main Methods:

  • Literature review of experimental knowledge on pentose phosphate pathways.

Related Experiment Videos

  • Analysis of molecular mechanisms in bacterial and eukaryotic systems.
  • Examination of enzyme roles in nucleoside and pentose phosphate metabolism.

    • Main Results:

    • Ribose-1-phosphate can be anabolized for pyrimidine salvage and 5-fluorouracil activation or recycled for nucleoside interconversion.
    • Nucleosides act as sugar carriers, made available by nucleoside phosphorylases in both bacteria and eukaryotes.
    • Bacterial nucleoside catabolism involves transporters and inducible enzymes when other energy sources are scarce.
    • Eukaryotic pentose phosphate production is modulated by developmental and physiological factors affecting enzyme levels.

    Conclusions:

    • Nucleoside phosphorylases play dual roles in catabolism and anabolism, impacting nucleotide and pentose phosphate metabolism.
    • Pentose phosphates derived from nucleosides are versatile metabolic intermediates in diverse organisms.
    • Understanding these pathways is crucial for comprehending cellular energy and biosynthesis strategies.