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Related Experiment Videos

Diffusion tensor imaging in early Alzheimer's disease.

Olivier Naggara1, Catherine Oppenheim, Dorothée Rieu

  • 1University Paris-Descartes, Faculty of Medecine, Department of Neuroradiology, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris, France. o.naggara@ch-sainte-anne.fr

Psychiatry Research
|March 8, 2006
PubMed
Summary

Early Alzheimer disease (AD) shows white matter (WM) damage in frontal and temporal lobes using diffusion tensor imaging (DTI). These DTI findings suggest early temporal-to-frontal disconnections in AD patients.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Alzheimer disease (AD) primarily affects grey matter, but white matter (WM) changes are also observed.
  • The precise nature of AD-associated WM damage remains unclear.

Purpose of the Study:

  • To investigate white matter tissue damage in early Alzheimer disease (AD) patients.
  • To utilize diffusion tensor imaging (DTI) to assess WM abnormalities.

Main Methods:

  • Diffusion tensor imaging (DTI) with b=1000 s/mm(2) and 25 directions was performed.
  • Compared mean diffusivity (MD) and fractional anisotropy (FA) in WM regions between 12 early AD patients and 12 controls.
  • Assessed whole brain volume and temporal lobe atrophy.

Main Results:

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  • Increased MD was observed in the splenium of the corpus callosum and frontal/parietal WM in AD patients.
  • Decreased FA was found bilaterally in temporal lobe, frontal lobe, and splenium WM.
  • No significant differences in other WM areas or correlation with MMSE scores.

Conclusions:

  • Diffusion tensor imaging (DTI) reveals abnormalities in frontal and temporal white matter in early Alzheimer disease (AD).
  • These findings are consistent with early temporal-to-frontal disconnections in AD.