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Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides
J A Secrist1, K N Tiwari, J M Riordan
1Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
Journal of Medicinal Chemistry
|August 1, 1991
Abstract:
2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.