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Updated: Aug 11, 2026
09:04
Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
Published on: November 19, 2019
Simultaneous venous gangrene in both lower and upper limbs. A case report
C N Bakoyiannis1, S E Georgopoulos, N S Tsekouras
1First Department of Surgery, University of Athens, Medical School, Laiko Hospital, Athens, Greece. bakogian@hotmail.com
Summary
This case study highlights an extremely rare paraneoplastic syndrome: cancer-related venous gangrene. Despite treatment, the condition progressed, emphasizing the high mortality associated with this rare cancer complication.
Area of Science:
- Oncology
- Vascular Surgery
- Hematology
Background:
- Cancer is a significant risk factor for venous thromboembolism.
- Paraneoplastic syndromes are rare complications of cancer.
- Venous gangrene is an exceptionally uncommon manifestation of cancer-related venous thromboembolism.
Observation:
- A patient with cervical cancer presented with venous gangrene in both upper and lower extremities.
- Standard treatments including anticoagulation and thrombolysis were ineffective.
- The gangrene progressed despite aggressive medical intervention.
Findings:
- This case illustrates the severe and aggressive nature of cancer-related venous gangrene.
- The condition can be refractory to conventional anticoagulant and thrombolytic therapies.
- Progression to multiple limbs can occur, even with optimal care.
Implications:
- Highlights the need for heightened awareness of rare paraneoplastic syndromes in cancer patients.
- Suggests that aggressive management strategies may be required for refractory cases.
- Underscores the poor prognosis and high mortality associated with advanced venous gangrene in cancer patients.
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