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ALDH2 polymorphisms and bone mineral density in an elderly Japanese population
J Yamaguchi1, Y Hasegawa, M Kawasaki
1Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai-Cho, Showa-ku, Nagoya, 4668550, Aichi, Japan. yamajin@rc5.so-net.ne.jp
Summary
The ALDH2Glu478Lys gene polymorphism is linked to increased osteoporosis risk, particularly in women. Individuals with the Lys/Lys genotype face a higher likelihood of developing osteoporosis.
Area of Science:
- Genetics
- Gerontology
- Bone Health
Background:
- Osteoporosis is a genetic disease increasing fracture risk in the elderly.
- Genetic factors play a significant role in osteoporosis development.
Purpose of the Study:
- To investigate the association between various gene polymorphisms and osteoporosis.
- To identify specific genetic markers related to osteoporosis risk.
Main Methods:
- Examined 403 community health screening participants for osteoporosis and 11 gene polymorphisms.
- Screened polymorphisms including ADH2, ALDH2, GST M1/T1, NQO1, IL-1B, TNF-alpha, ecNOS, mtDNA 5178, IL-4, and CD14.
Main Results:
- A significant association was found between ALDH2Glu478Lys gene polymorphisms and osteoporosis.
- The Lys/Lys genotype showed a significantly elevated osteoporosis morbidity rate (OR: 3.33), especially in women (OR: 4.31).
Conclusions:
- The ALDH2Glu478Lys polymorphism is a risk factor for osteoporosis.
- Prophylactic interventions should target non-carriers of the Glu allele (Lys/Lys genotype).