[Effect of ammonium perchlorate on calcium currents in neurons and leukocyte mobility]

NH4ClO4 has been studied for its effect on the voltage-activated calcium current (ICa) in voltage-clamp experiments on intracellularly perfused snail neurons and on the chemokinesis of rat leukocytes. It has been found that NH4ClO4 enhances ICa amplitude 1.5-5 times (EC50 = 3 mmol/l), decreases the rate of ICa decay and stimulates mobility of leukocytes 3 times (EC50 = 2.5 mmol/l). It is suggested that these changes may be intermediated by similar mechanisms, e.g. by an increase in intracellular pH.