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Related Experiment Videos

The diabetic myocardium.

Thomas H Marwick1

  • 1University of Queensland Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD 4102, Australia. tmarwick@soms.uq.edu.au

Current Diabetes Reports
|March 9, 2006
PubMed
Summary
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Diabetes mellitus can cause a specific heart muscle disease, leading to diastolic and systolic dysfunction. Better glycemic control and certain treatments may improve outcomes for diabetic cardiomyopathy.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Diabetes mellitus and heart failure frequently coexist.
  • Diabetes can worsen heart failure following other cardiac insults.
  • Evidence suggests a distinct primary myocardial disease in diabetes.

Purpose of the Study:

  • To review the evidence for a specific primary myocardial disease in diabetes.
  • To explore the mechanisms underlying diabetic heart disease.
  • To identify potential therapeutic strategies.

Main Methods:

  • Review of clinical evidence and sensitive echocardiographic studies.
  • Analysis of multifactorial mechanisms including metabolic, structural, and autonomic factors.
  • Examination of the role of glycemic control and therapeutic interventions.

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Main Results:

  • Diastolic dysfunction is detectable in asymptomatic diabetic subjects.
  • Systolic disturbances are also identified using sensitive echocardiographic markers.
  • Mechanisms involve myocyte metabolism, cardiac structure, autonomic neuropathy, and coronary disease.

Conclusions:

  • Diabetes is associated with a specific heart muscle disease.
  • Multifactorial mechanisms contribute to diabetic cardiomyopathy.
  • Improved glycemic control and interventions like ACE inhibition show promise.