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Updated: Aug 10, 2026
05:10
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Climacteric obesity: from genesis to clinic
Andrzej Milewicz1, Diana Jedrzejuk
1Department of Endocrinology, Diabetology, and Isotope Treatment, University of Medicine, Wroclaw, Poland. milewicz@endo.am.wroc.pl
Summary
Obesity has many causes, including genetics and aging. This study presents diagnostic and therapeutic strategies for obesity in postmenopausal women, focusing on the visceral type linked to metabolic risks.
Area of Science:
- Endocrinology
- Metabolism
- Genetics
Background:
- The causes of obesity are complex and not fully understood, involving genetic, hormonal, and lifestyle factors.
- Aging, particularly menopause, influences obesity, especially the visceral (abdominal) fat distribution.
- Visceral obesity is associated with increased risks of type 2 diabetes and cardiovascular disease.
Purpose of the Study:
- To explore the multifactorial etiology of obesity.
- To present diagnostic-therapeutic algorithms for climacteric obesity.
- To highlight the risks associated with the visceral obesity phenotype in postmenopausal women.
Main Methods:
- Review of genetic factors (gene polymorphisms) and hormonal peptides (leptin, neuropeptide Y).
- Consideration of aging-related changes (growth hormone, dehydroepiandrosterone) and sympathetic nervous system activity.
- Analysis of sex steroids, inflammatory factors, and nutritional patterns.
Main Results:
- Identified several candidate genes and hormonal peptides implicated in obesity.
- Highlighted the specific risks of visceral obesity in postmenopausal women, including metabolic disorders.
- Emphasized the role of aging and hormonal changes in obesity development.
Conclusions:
- Obesity is a multifactorial condition influenced by genetics, hormones, aging, and lifestyle.
- Diagnostic and therapeutic algorithms are crucial for managing climacteric obesity.
- Understanding obesity phenotypes is key to mitigating associated health risks like type 2 diabetes and cardiovascular disease.
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