Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Breast cancer and scleroderma.

Alon Scope1, Siegal Sadetzki, Yechezkel Sidi

  • 1Department of Dermatology, Chaim Sheba Medical Center, The Sackler School of Medicine, Tel Aviv University, Israel. a_scope@netvision.net.il

Skinmed
|March 9, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Insights and Prognostic Factors in Frontal Fibrosing Alopecia and Lichen Planopilaris: A Retrospective Cohort Study.

Dermatology (Basel, Switzerland)·2026
Same author

Pregnancy outcomes in patients with biologic-exposed psoriasis: A large cohort study of real-world safety.

Journal of the American Academy of Dermatology·2026
Same author

From Onset to Outcome: A Long-term Retrospective, Single centre Study of Guttate Psoriasis from Israel.

Acta dermato-venereologica·2026
Same author

Efficacy of glucagon-like peptide 1 analogues in psoriasis: A cohort study.

JAAD international·2026
Same author

The MATRIX criteria: an internally validated scoring model for biopsy selection in longitudinal melanonychia.

The British journal of dermatology·2026
Same author

Factors Associated With Treatment Response in Granuloma Annulare.

Photodermatology, photoimmunology & photomedicine·2026

Scleroderma patients face a higher cancer risk. This study reviewed 65 cases of breast cancer and scleroderma, finding associations that warrant further investigation into this complex relationship.

Area of Science:

  • Rheumatology
  • Oncology
  • Epidemiology

Background:

  • Epidemiologic studies indicate an elevated cancer risk in patients diagnosed with scleroderma.
  • Scleroderma, a chronic connective tissue disease, presents in cutaneous and systemic forms.
  • The potential link between scleroderma and specific cancers, such as breast cancer, requires further elucidation.

Purpose of the Study:

  • To investigate the association between breast cancer and scleroderma (both cutaneous and systemic forms).
  • To review clinical data of patients with both conditions.
  • To identify patterns in the occurrence of scleroderma relative to breast cancer diagnosis.

Main Methods:

  • Retrospective review of eight patient cases hospitalized between 1980-2002.
  • Comprehensive literature search for published data on breast cancer and scleroderma.

Related Experiment Videos

  • Analysis of clinical data from a total of 65 women with both diagnoses.

    • Main Results:

    • Scleroderma preceded or coincided with breast cancer diagnosis in 44% of patients.
    • A higher frequency of systemic scleroderma was observed when it appeared before or concurrently with breast cancer.
    • Cutaneous scleroderma showed a higher incidence when it followed a breast cancer diagnosis (p<0.001).

    Conclusions:

    • The findings suggest a potential association between scleroderma and breast cancer.
    • Further large-scale case-control studies are necessary to confirm these associations.
    • Distinguishing between cutaneous and systemic scleroderma in relation to breast cancer timing may be significant.