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[The time scale in poxvirus evolution].

I V Babkin, S N Shchelkunov

    Molekuliarnaia Biologiia
    |March 10, 2006
    PubMed
    Summary
    This summary is machine-generated.

    This study estimates the molecular clock for DNA viruses, revealing mutation rates of 0.9-1.2 x 10^-6 substitutions per site per year. Poxviruses diverged into modern genera around 500,000 years ago.

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    Area of Science:

    • Virology
    • Molecular Evolution
    • Genomics

    Context:

    • Objective molecular clock estimates were lacking for DNA-containing viruses, unlike vertebrates and RNA viruses.
    • Poxviridae family viruses, including orthopoxviruses, were analyzed using genomic and gene sequences.
    • Phylogenetic data of variola virus (VARV) isolates informed the molecular clock calibration.

    Purpose:

    • To establish the first objective molecular clock estimate for DNA-containing viruses.
    • To determine the mutation rate and evolutionary divergence times within the Poxviridae family.
    • To analyze conserved genomic regions and DNA polymerase genes for evolutionary insights.

    Summary:

    • Calculated a mutation rate of 0.9-1.2 x 10^-6 substitutions per site per year for poxviruses.

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  • Estimated that poxviruses diverged into modern genera approximately 500,000 years ago.
  • Determined the ancestor of the Orthopoxvirus genus separated ~300,000 years ago, with species divergence ~14,000 years ago.

    • Impact:

    • Provides a crucial molecular clock reference for DNA viruses.
    • Enhances understanding of poxvirus evolution and diversification.
    • Establishes a framework for dating evolutionary events in DNA viruses.