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Human parvovirus B19 and its associated diseases

M L Kumar1

  • 1Case Western Reserve University School of Medicine, Cleveland, Ohio.

Clinics in Perinatology
|June 1, 1991
PubMed

Insights

Parvovirus B19 infection in pregnant women poses risks to offspring, including stillbirth. However, ongoing studies suggest adverse pregnancy outcomes are less common than previously thought.

Area of Science:

  • Obstetrics and Pediatrics
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Parvovirus B19 infection during pregnancy can lead to intrauterine infection.
  • Previous estimates of adverse pregnancy outcomes associated with B19 infection were based on retrospective data.
  • Concerns persist regarding severe outcomes like nonimmune hydrops fetalis and stillbirth.

Purpose of the Study:

  • To evaluate the current understanding of B19 infection in pregnant women.
  • To assess the risks of adverse pregnancy outcomes following maternal B19 infection.
  • To emphasize the importance of physician familiarity with B19 in pregnancy.

Main Methods:

  • Prospective studies of B19 infection in pregnant women.
  • Review of existing literature and case reports.
  • Analysis of pregnancy outcomes in relation to maternal B19 status.

Main Results:

  • Ongoing prospective studies indicate a lower risk of adverse pregnancy outcomes than previously estimated.
  • A small percentage of offspring may still experience severe outcomes, including nonimmune hydrops or stillbirth.
  • Physicians need to be aware of B19 infection risks during pregnancy.

Conclusions:

  • While risks are lower than previously thought, Parvovirus B19 infection in pregnancy remains a concern.
  • Vigilance and familiarity with B19 are crucial for obstetricians and pediatricians.
  • Further research may refine risk assessment and management strategies.

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