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Relationship between plasma total antioxidant capacity and thoracic aortic intima-media thickness

Recep Demirbag1, Remzi Yilmaz, A Sami Kunt

  • 1Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey. rdemirbag@yahoo.com

Echocardiography (Mount Kisco, N.Y.)
|March 10, 2006
PubMed

Insights

Total antioxidant capacity (TAC) is linked to a lower risk of thoracic aortic atherosclerosis. Lower TAC levels correlate with increased thoracic aortic intima-media thickness (TAIMT) and atherosclerosis severity.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Medical Imaging

Background:

  • Antioxidants play a crucial role in preventing coronary artery disease (CAD).
  • Low total antioxidant capacity (TAC) is a known risk factor for ischemic heart disease.
  • Limited data exist on the relationship between TAC and thoracic aortic atherosclerosis severity.

Purpose of the Study:

  • To investigate the association between total antioxidant capacity (TAC) and atherosclerotic thoracic aortic intima-media thickness (TAIMT).
  • To determine if TAC is an independent predictor of thoracic aortic atherosclerosis.

Main Methods:

  • Utilized multiplane transesophageal echocardiography (TEE) to assess TAIMT and the grade of thoracic aortic atherosclerosis.
  • Measured TAC in 29 patients without a history of cardiovascular disease, excluding those with obesity, hypertension, diabetes, or CAD.
  • Employed a recently developed method for TAC measurement.

Main Results:

  • A significant negative correlation was observed between TAC levels and both TAIMT (r = -0.799) and the grade of thoracic aortic atherosclerosis (r = -0.827).
  • Multiple linear regression confirmed TAC as an independent predictor of TAIMT (beta = -0.734).
  • TAC levels progressively decreased with increasing grades of thoracic aortic atherosclerosis (Grade I: 2.23 ± 0.31; Grade II: 1.58 ± 0.31; Grade III: 1.04 ± 0.27 mmol Trolox equiv/l; ANOVA P < 0.001).

Conclusions:

  • Total antioxidant capacity (TAC) is an independent variable associated with thoracic aortic intima-media thickness (TAIMT).
  • TAC may serve as an independent predictor for atherosclerotic lesions in major arteries.
  • Findings suggest TAC's potential role in assessing the risk and severity of aortic atherosclerosis.

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