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Published on: August 1, 2018
Expression of HER1/EGFR protein in human soft tissue sarcomas
J-L Yang1, M T Hannan, P J Russell
1Oncology Research Centre, School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. j.yang@unsw.edu.au
Aim:
To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples.
Method:
HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients.
Results:
HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues.
Conclusion:
HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.

