Related Experiment Video
Updated: Aug 10, 2026
Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK
Ya-Ming Xu1, Jeffrey A Smith, Deborah A Lannigan
1Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22901, USA.
Abstract:
A survey of plant extracts for the presence of p90 ribosomal S6 kinase (RSK) inhibitors resulted in the isolation of three acetylated flavonol glycosides. Kaempferol 3-O-(2'',4''-O-diacetyl-alpha-l-rhamnopyranoside) (1), kaempferol 3-O-(3'',4''-O-diacetyl-alpha-l-rhamnopyranoside) (2), and kaempferol-3-O-(4''-O-acetyl-alpha-l-rhamnopyranoside) (3) were isolated from Forsteronia refracta as the first RSK inhibitors. Of these, compound 2 was found to be the best inhibitor with an IC(50) value of 89 nM.