Related Experiment Video
Updated: Aug 10, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[The expression and activity of protein kinase A I in oral squamous cell carcinoma]
Chang-feng Qu1, De-hao Shang, Zhong-zheng Qi
1Department of Oral and Maxillofacial Surgery, Dalian Central Hospital, Dalian 116033, Liaoning Province, China.
Purpose:
To detect the expression and distribution of protein kinase A I (PKA I) in oral squamous cell carcinoma as well as its clinicalpathological significance.
Methods:
The expression of PKA I was investigated in 40 oral squamous cell carcinomas and 15 normal tissues by immunohistochemistry. The activity of PKAI was detected in 20 human oral squamous cell carcinomas and adjacent normal tissues with Western blot. The data was analysed with SPSS 11.5 for Student's t test, Chi-between different square test and linear correlation analysis.
Results:
The expression of PKA I was significantly higher in oral squamous cell carcinomas than in normal tissues (P<0.05). There were no differences degrees of histodifferentiation and clinical phases (P>0.05). The activity of PKA I was significantly higher in oral squamous cell carcinomas than in normal tissues (P<0.01), there were obvious dependability of the expression and activity of PKA I (P<0.01).
Conclusions:
Protein kinase A I highly expressed in oral squamous cell carcinomas, but was not related to the degree of histodifferentiation and the clinical phases. Oral squamous cell carcinoma correlated with the expression and activity of PKA I and the activation of PKA I was one of the factors for proliferation of oral squamous cell carcinoma.
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
Abnormal Proliferation
Inhibition of Cdk Activity
Inhibition of CDK Activity
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...