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Gait abnormalities induced by acquired bilateral pallidal lesions: a motion analysis study
P Krystkowiak1, A Delval, K Dujardin
1Neurologie A, Hôpital R. Salengro, CHRU de Lille, 59037, Lille Cedex, France. p-krystkowiak@chru-lille.fr
Journal of Neurology
|March 10, 2006
Summary
Bilateral pallidal lesions cause parkinsonian symptoms, including gait and gait initiation issues like akinesia, hypokinesia, and bradykinesia, similar to Parkinson's disease.
Area of Science:
- Neuroscience
- Movement Disorders
- Clinical Neurology
Background:
- Bilateral pallidal lesions can lead to parkinsonian syndromes with significant gait and gait initiation disturbances.
- The exact clinical manifestations and the pallidum's role in these disorders require further elucidation.
Observation:
- Gait and gait initiation kinematic and kinetic parameters were analyzed in two patients with bilateral pallidal lesions (PAL) using VICON motion analysis.
- These PAL patients were compared to 17 Parkinson's disease (PD) patients and 20 healthy controls.
Findings:
- Both PAL and PD patients exhibited similar impairments in gait and gait initiation parameters.
- Key findings included akinesia (impaired anticipatory postural adjustments), hypokinesia (reduced stride length), and bradykinesia (reduced gait speed).
Implications:
- Gait and initiation disorders in bilateral pallidal lesions mirror those seen in Parkinson's disease.
- Bipallidal patients may experience higher-level gait disorders potentially linked to cognitive impairments, warranting further investigation.
