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[Are the Spanish hypertensive children therapeutic orphans?]

C Morales-Carpi1, L Estañ Yago, I Torró Doménech

  • 1Unidad Riesgo Cardiovascular, Servicio de Pediatría, Consorcio Hospital General Universitario, Valencia, Spain.

Anales De Pediatria (Barcelona, Spain : 2003)
|March 11, 2006
PubMed

Insights

Pediatric hypertension treatment lacks sufficient drug information. The International Vademecum (I-V) provides guidance for only 5 antihypertensive drugs, leaving children as therapeutic orphans.

Area of Science:

  • Pediatric Pharmacology
  • Cardiovascular Medicine
  • Drug Information Science

Context:

  • Current guidelines recommend adult antihypertensive drugs for children, with dose adjustments for body size.
  • The term "therapeutic orphans" highlights the scarcity of pediatric drug usage data.
  • Investigating the adequacy of the International Vademecum (I-V) for pediatric antihypertensive drug use is crucial.

Purpose:

  • To assess the sufficiency of the International Vademecum (I-V) for guiding the correct use of antihypertensive drugs in pediatric populations.
  • To compare I-V data with established pediatric hypertension guidelines, such as the NHBPEP Fourth Report.

Summary:

  • A review of 111 entries for 41 antihypertensive drugs in the I-V (44th & 45th editions) revealed limited pediatric information.
  • Only 5 drug classes (3 diuretics, 2 ACE inhibitors) had available pediatric dosage information in the I-V.
  • In contrast, the NHBPEP Fourth Report lists pediatric dosages for 28 drugs, and the FDA has approved 10 for pediatric use.

Impact:

  • The I-V provides inadequate information for safe and effective pediatric antihypertensive drug dosing.
  • Children remain "therapeutic orphans" due to the lack of comprehensive drug information for their age group.
  • This study underscores the need for improved drug data accessibility for pediatric hypertension management.
Abstract

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