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The effects of topical ketorolac and indomethacin on measles conjunctivitis: randomized controlled trial
Mustafa Ilker Toker1, Hakan Erdem, Haydar Erdogan
1Department of Ophthalmology, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey. ilkertoker@cumhuriyet.edu.tr
Purpose:
To compare the effect of topical ketorolac and indomethacin on measles conjunctivitis.
Design:
Prospective double-masked placebo-controlled randomized trial.
Methods:
Sixty-two patients with severe measles conjunctivitis were included in this study. All patients were hospitalized and randomly assigned to receive ketorolac 0.5% or indomethacin 0.1% in the right eye and artificial tears in the left eye. Conjunctival hyperemia, burning sensations, foreign-body sensations, and photophobia scores were conducted at baseline and at days seven and 14. A satisfaction score was evaluated at the end of the study.
Results:
The conjunctival injection score of the control eyes was significantly higher than those of the ketorolac- and indomethacin-treated eyes at day seven (P < .05). The conjunctival injection score of the ketorolac-treated eyes was lower than that of the indomethacin-treated eyes at days seven and 14, but this did not reach statistical significance. There was no significant difference in the burning and foreign-body sensations and in the photophobia scores among the study eyes at baseline, day seven, and day 14 (P > .05). There was no significant difference in the satisfaction score among the study eyes at the end of the study (P > .05).
Conclusions:
In patients with measles during the first two weeks of infection, ketorolac and indomethacin were more effective than artificial tears in decreasing conjunctival hyperemia, but burning sensations, foreign-body sensations, and photophobia were unaffected.
