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Updated: Aug 10, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
Adalimumab-associated optic neuritis
Jacob H Chung1, Gregory P Van Stavern, Larry P Frohman
1Institute of Ophthalmology and Visual Science, UMDNJ-New Jersey Medical School, P.O. Box 1709, Newark, NJ 07101-1709, USA.
Abstract:
We present, to our knowledge, the first published cases of optic neuritis associated with adalimumab, a medication in the class of anti-tumor necrosis factor-alpha (TNF-alpha) antagonists. Approved in recent years by the FDA, adalimumab (Humira, Abbott Laboratories; Abbott Park, IL) is a recombinant monoclonal antibody that targets and blocks the physiologic effects of TNF. Other TNF antagonists have had associations with optic neuritis and demyelinating events.
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