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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
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Related Experiment Video

Updated: Jan 11, 2026

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CD137-mediated immunotherapy for allergic asthma.

Tobias Polte1, Juergen Foell, Christoph Werner

  • 1Division of Pediatric Pulmonology and Neonatology, Medizinische Hochschule Hannover, Hannover, Germany.

The Journal of Clinical Investigation
|March 11, 2006
PubMed
Summary

A single injection of anti-CD137 (4-1BB) monoclonal antibody (mAb) effectively reversed established allergic asthma in mice. This immunotherapy approach shows promise for treating asthma by modulating immune responses.

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Area of Science:

  • Immunology
  • Allergy Research
  • Therapeutic Development

Background:

  • Asthma prevalence is rising, driven by Th2 immune responses.
  • Current asthma treatments are insufficient, necessitating novel immunotherapies.

Purpose of the Study:

  • To investigate the therapeutic potential of anti-CD137 (4-1BB) monoclonal antibody (mAb) in a murine asthma model.
  • To elucidate the immune mechanisms underlying anti-CD137 mAb-mediated asthma amelioration.

Main Methods:

  • Administration of anti-CD137 mAb in a murine model of allergic asthma.
  • Assessment of airway hyperreactivity, inflammation, mucus production, and IgE levels.
  • Analysis of T cell populations, cytokine profiles (Th1/Th2), and B lymphocyte counts.

Main Results:

  • A single anti-CD137 mAb injection prevented and reversed asthma symptoms, including airway hyperreactivity and inflammation.
  • Treatment led to reduced Th2 cytokines, increased Th1 cytokine (IFN-gamma) production, and altered lymphocyte populations.
  • CD4+ T cell anergy was identified as critical for the protective effects.

Conclusions:

  • Anti-CD137 (4-1BB) mAb demonstrates significant therapeutic capacity for ameliorating allergic asthma.
  • CD137 represents a promising target for developing new immunotherapies for asthma.