Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Needle shear wave driver for magnetic resonance elastography.

Q C C Chan1, G Li, R L Ehman

  • 1Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong.

Magnetic Resonance in Medicine
|March 11, 2006
PubMed
Summary

Magnetic resonance elastography (MRE) using a novel needle driver accurately estimates tissue stiffness. This method offers advantages over surface drivers for targeted MRE assessments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neratinib + fulvestrant + trastuzumab for HR-positive, HER2-negative, HER2-mutant metastatic breast cancer: outcomes and biomarker analysis from the SUMMIT trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Evaluation of immunologic parameters in canine glioma patients treated with an oncolytic herpes virus.

Journal of translational genetics and genomics·2022
Same author

Reply to "Phase II prospective randomized trial of weight loss prior to radical prostatectomy".

Prostate cancer and prostatic diseases·2018
Same author

The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models.

Oncogene·2015
Same author

The expression of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and HCN2 in the rat trigeminal ganglion, sensory root, and dental pulp.

Neuroscience·2015
Same author

The intersection between DNA damage response and cell death pathways.

Experimental oncology·2012

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Rheology

Background:

  • Magnetic resonance elastography (MRE) quantifies tissue mechanical properties in vivo.
  • Conventional MRE uses surface mechanical excitation to generate shear waves.
  • Limitations exist in precise localization and potential orientation-related errors with surface drivers.

Purpose of the Study:

  • To introduce and evaluate a novel MRE method utilizing an inserted needle to generate shear waves.
  • To compare the accuracy and effectiveness of needle-driven MRE with traditional surface-driven MRE.
  • To assess the potential of needle-driven MRE for targeted stiffness estimation.

Main Methods:

  • Development of a needle driver system to generate shear waves within targeted tissues.

Related Experiment Videos

  • Acquisition of MRE data using both needle and surface drivers in animal models.
  • Quantitative comparison of shear stiffness estimates obtained from both methods against mechanical testing.
  • Analysis of wave propagation patterns to evaluate section orientation-related errors.

    • Main Results:

    • MRE with the needle driver provided shear stiffness estimates that correlated well with mechanical testing.
    • Needle-driven MRE showed comparable results to surface-driven MRE.
    • The needle driver facilitated a well-defined wave propagation pattern, reducing orientation-related errors in targeted regions.
    • Preliminary animal testing demonstrated the feasibility and effectiveness of the needle driver.

    Conclusions:

    • Needle-driven MRE is an effective technique for quantitative tissue stiffness assessment.
    • This method offers advantages over surface drivers, particularly for targeted regions and reducing specific estimation errors.
    • The needle driver presents a promising advancement for MRE applications requiring precise localization and accuracy.