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Updated: Aug 10, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
Published on: July 16, 2021
[Amyotrophic lateral sclerosis in younger age associated with abnormality of copper level]
Omer C Ibrahimagić1, Osman Sinanović, Lejla Zonić
1Klinika za Neurologiju, Univerzitetski Klinicki Centar Tuzla.
Abstract:
Amyotrophic lateral sclerosis is a progressive degenerative neuromuscular disease in adults that occurs in familial and sporadic forms. The mean age of onset of symptoms is 56 years and the mean duration of disease is 3 years. One of the theories on the pathogenesis suggests on mutation in gene that encodes superoxide dismutase, which is involved in metabolism of free radicals (copper, zinc). In this article we showed patient with early onset of disease associated with abnormality of copper level. Co morbidity with Wilson disease has not been proved. According to this case it is possible to think about changes in cuprum level at ALS patients.
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