Management of Hodgkin lymphoma

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Updated: Aug 10, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

Stephen M Ansell1, James O Armitage

  • 1Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA. ansell.stephen@mayo.edu

Mayo Clinic Proceedings
|March 15, 2006
PubMed

Insights

Hodgkin lymphoma (HL) affects young adults and the elderly, with over 80% of patients achieving long-term survival. However, new therapies are needed for patients with resistant disease or relapse after treatment.

Area of Science:

  • Oncology
  • Hematology
  • Clinical Medicine

Background:

  • Hodgkin lymphoma (HL) is diagnosed in approximately 7350 US patients annually.
  • HL incidence exhibits a bimodal pattern, peaking in young adults and the elderly.
  • Classical HL and nodular lymphocyte-predominant HL are the two main disease entities.

Purpose of the Study:

  • To provide an overview of Hodgkin lymphoma diagnosis and treatment.
  • To highlight current survival rates and challenges in HL management.
  • To underscore the need for novel therapeutic strategies.

Main Methods:

  • Review of epidemiological data for Hodgkin lymphoma incidence.
  • Description of Hodgkin lymphoma classification and staging.
  • Summary of current treatment modalities for early and advanced stages.

Main Results:

  • Over 80% of newly diagnosed Hodgkin lymphoma patients are expected to be long-term survivors.
  • Combined modality treatment (chemotherapy and radiation) is standard for early-stage disease.
  • Advanced-stage disease is treated with chemotherapy, with radiation omitted.

Conclusions:

  • While cure rates are high, a subset of patients develops resistant disease or relapses.
  • Salvage therapies like high-dose chemotherapy and autologous stem cell transplantation are used for refractory cases.
  • Development of innovative therapies is crucial for improving outcomes in relapsed or refractory Hodgkin lymphoma.

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