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Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced
B H Davis1, U R Rapp, N O Davidson
1Department of Medicine, University of Chicago, IL 60637.
The Biochemical Journal
|August 15, 1991
Abstract:
Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor beta (TGF beta) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGF beta blocked PDGF-induced cell proliferation. TGF beta, but not retinoic acid, diminished PDGF-receptor and smooth-muscle alpha-actin abundance.