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The synthesis and use of boronated amino acids for boron neutron capture therapy
George W Kabalka1, Min-Liang Yao
1Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, TN 37996-1600, USA. kabalka@utk.edu
Abstract:
The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.
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