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Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy
1Wageningen University and Research Center, Animal Sciences Group, PO Box 65, 8200 AB Lelystad, The Netherlands. FranzJosef.vanderStaay@wur.nl
Brain Research Reviews
|March 15, 2006
Summary
Animal models in neuroscience help study brain-behavior links for human conditions. Rigorous criteria, standardization, and validation are crucial for developing reliable and relevant animal models of behavioral dysfunctions.
Area of Science:
- Behavioral neurosciences
- Neurobiology
- Biopsychology
Background:
- Animal models are essential tools in behavioral neurosciences for investigating brain-behavior relationships.
- These models aim to provide insights into normal and abnormal human behavior, including underlying neuronal and neuroendocrinological processes.
Purpose of the Study:
- To review different types of animal models for behavioral dysfunctions.
- To define precise criteria for developing and evaluating animal models of human behavioral dysfunctions.
Main Methods:
- Expert consensus on neuropathologic and behavioral characteristics.
- Translating behavioral phenotypes into testable experimental measures.
- Standardizing rearing, housing, and testing conditions.
- Evaluating reliability, validity (predictive, construct), and biological/clinical relevance.
Main Results:
- The development of animal models requires a systematic evaluation strategy.
- Criteria for model development are purpose-dependent.
- Reliability, validity, and relevance are key evaluation metrics.
Conclusions:
- Establishing robust criteria and systematic evaluation is vital for effective animal models in neuroscience research.
- Responsible use of animals in research is a necessary consideration.