Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obesity and asthma: cause for concern.

Stephanie A Shore1

  • 1Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston MA 02115, USA. sshore@hsph.harvard.edu

Current Opinion in Pharmacology
|March 15, 2006
PubMed
Summary

Obesity increases asthma risk and severity, preceding the condition. Understanding the link between obesity and asthma could reveal new treatments for affected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness.

Nature communications·2023
Same author

The Gut Microbiome and Ozone-induced Airway Hyperresponsiveness. Mechanisms and Therapeutic Prospects.

American journal of respiratory cell and molecular biology·2020
Same author

Gut microbiota from androgen-altered donors alter pulmonary responses to ozone in female mice.

Physiological reports·2020
Same author

IL-33, diet-induced obesity, and pulmonary responses to ozone.

Respiratory research·2020
Same author

Early life microbiome perturbation alters pulmonary responses to ozone in male mice.

Physiological reports·2020
Same author

Sex Differences in the Impact of Dietary Fiber on Pulmonary Responses to Ozone.

American journal of respiratory cell and molecular biology·2020

Area of Science:

  • Pulmonary Medicine
  • Metabolic Disease Research
  • Epidemiology

Background:

  • Obesity is a recognized risk factor for developing asthma.
  • Obesity is associated with increased asthma severity and precedes asthma onset.
  • Weight loss improves asthma symptoms, and obese mice exhibit airway hyperresponsiveness.

Purpose of the Study:

  • To explore the mechanistic basis of the relationship between obesity and asthma.
  • To identify potential therapeutic targets for asthma in obese individuals.

Main Methods:

  • Review of epidemiological data linking obesity and asthma.
  • Analysis of findings from animal models of obesity and asthma.
  • Consideration of potential contributing factors such as common etiologies, comorbidities, lung volume changes, and adipokines.

Main Results:

  • Epidemiological evidence strongly supports obesity as a risk factor and a factor in asthma severity.
  • Obesity precedes asthma development.
  • Obese mice demonstrate innate airway hyperresponsiveness.

Conclusions:

  • The relationship between obesity and asthma is supported by multiple lines of evidence.
  • Potential mechanisms include shared causes, comorbidities, mechanical effects on the lungs, and adipokine signaling.
  • Further research into the mechanistic basis is crucial for developing novel therapeutic strategies for obese asthma patients.

Related Experiment Videos